The Anti-Hu CD45R0 PE-DyLight 594 Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human antigen. The Anti-Hu CD45R0 PE-DyLight 594 Antibody has been validated for the following applications: Flow Cytometry.
Description
CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells